期刊
ACS SENSORS
卷 2, 期 10, 页码 1452-1457出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.7b00385
关键词
glass capillary nanopores; DNA translocation; signal enhancement; nanotechnology; silanization
资金
- National Science Foundation of China [21305136, 21475125]
- Instrument Developing Project of the Chinese Academy of Sciences [YZ201666]
- State Key Laboratory of Electroanalytical Chemistry [110000R387]
Diameter is a major concern for nanopore based sensing. However, directly pulling glass capillary nanopore with diameter down to sub-10 nm is very difficult. So, post treatment is sometimes necessary. Herein, we demonstrate a facile and effective wet-chemical method to shrink the diameter of glass capillary nanopore from several tens of nanometers to sub-10 nm by disodium silicate hydrolysis. Its benefits for DNA translocation are investigated. The shrinking of glass capillary nanopore not only slows down DNA translocation, but also enhances DNA translocation signal and signal-to-noise ratio significantly (102.9 for 6.4 nm glass nanopore, superior than 15 for a 3 nm silicon nitride nanopore). It also affects DNA translocation behaviors, making the approach and glass capillary nanopore platform promising for DNA translocation studies.
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