期刊
GENES & DISEASES
卷 3, 期 1, 页码 56-71出版社
ELSEVIER
DOI: 10.1016/j.gendis.2015.09.004
关键词
Bone regeneration; Craniofacial defects; Osteogenesis; Regenerative medicine; Scaffolds; Tissue engineering
资金
- Chicago Biomedical Consortium
- Searle Funds at The Chicago Community Trust (RRR, GA)
- NIH/NIDCK Career Development Award [1K08 DE020140-01]
- Pritzker Summer Research Fellowship through a National Institutes of Health (NIH) T-35 training grant (NIDDK)
- Pritzker Research Fellowship
- Howard Hughes Medical Institute Medical Research Fellowship
Current reconstructive approaches to large craniofacial skeletal defects are often complicated and challenging. Critical-sized defects are unable to heal via natural regenerative processes and require surgical intervention, traditionally involving autologous bone (mainly in the form of nonvascularized grafts) or alloplasts. Autologous bone grafts remain the gold standard of care in spite of the associated risk of donor site morbidity. Tissue engineering approaches represent a promising alternative that would serve to facilitate bone regeneration even in large craniofacial skeletal defects. This strategy has been tested in a myriad of iterations by utilizing a variety of osteoconductive scaffold materials, osteoblastic stem cells, as well as osteoinductive growth factors and small molecules. One of the major challenges facing tissue engineers is creating a scaffold fulfilling the properties necessary for controlled bone regeneration. These properties include osteoconduction, osteoinduction, biocompatibility, biodegradability, vascularization, and progenitor cell retention. This review will provide an overview of how optimization of the aforementioned scaffold parameters facilitates bone regenerative capabilities as well as a discussion of common osteoconductive scaffold materials. Copyright (C) 2015, Chongqing Medical University. Production and hosting by Elsevier B.V.
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