Investigation of collagen/tricalcium silicate/carboxymethyl cellulose composite bone glue for drug controlled release

A novel bone glue composed of tricalcium silicate and high proportion of type I collagen is proposed. Tricalcium silicate (C3S) is one of the most promising biomedical materials on bone cement due to its excellent biocompatibility and self- curing properties. By adding the type I collagen and carboxymethyl cellulose (CMC) to increase the adhesion and biocompatibility to the human tissue, the proposed composite bone glue shows excellent adhesive strength to 416 kPa, tensile strength to 167 kPa, and increasing mechanical strength after curing in simulated body fluid. Furthermore, results of diclofenac sodium drug releasing test show that after 2 days, the release increased from 46 to 53% and then maintained about 53%. Among all different collagen to C3S ratio, 40 wt% collagen and 60 wt% C3S composite bone glue has