期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 3, 期 2, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1079672
关键词
Androgen receptor; angiogenin; breast cancer; cyclic phosphate; estrogen receptor; prostate cancer; SHOT-RNA; tRNA; tRNA fragment; tRNA half
类别
资金
- NIH grant [GM106047]
- JSPS
Sex hormones and their receptors play critical roles in the genesis and progression of breast and prostate cancers. We recently discovered that sex hormone signaling pathways promote the expression of specific tRNA halves termed Sex HOrmone-dependent TRNA-derived RNAs (SHOT-RNAs). Functional involvement of SHOT-RNAs in cell proliferation suggests a novel tRNA-engaged pathway in tumorigenesis.
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