Nanocomposite modified electrochemical sensor for sensitive and selective determination of noradrenaline

A glassy carbon electrode was modified withgraphene-chitosan nanocomposite for the sensitive and selective determination of noradrenaline. The morphological characteristics of nanocomposite were studied by scanning electron microscope and atomic force microscopy. Electrochemical characterization of the modified sensor was done using cyclic voltammetry and electrochemical impedance spectroscopy. Enhancement in electron transfer process and reduction in charge transfer resistance was observed. The electrochemical behavior of noradrenaline at nanocomposite modified sensor was investigated in pH 7.4 phosphate buffer solution using cyclic voltammetry and square wave voltammetry. The modified sensor showed high sensitivity and selectivity for the determination of noradrenaline. The method was also successfully employed for determination of noradrenaline in a pharmaceutical formulation. (C) 2015 Elsevier Ltd. All rights reserved.