期刊
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
卷 6, 期 4, 页码 -出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/tvst.6.4.6
关键词
adaptive optics; glaucoma; retinal nerve fiber
资金
- National Eye Institute (NEI) of the National Institutes of Health (Bethesda, MD) [R01EY02115, R01EY025231, U01EY025477]
- Joseph and Marilyn Rosen Research Fund of the New York Glaucoma Research Institute
- Glaucoma Research Foundation Catalyst for a Cure Initiative
- Marrus Family Foundation
- Wise Family Foundation
- Lowenstein Foundation
- New York Eye and Ear Chairman's Research Fund
- Violett Fund, Milbank Foundation
Purpose: Deep glaucomatous defects near fixation were followed over time with an adaptive optics-scanning light ophthalmoscope (AO-SLO) to better understand the progression of these defects and to explore the use of AO-SLO in detecting them. Methods: Six eyes of 5 patients were imaged with an AO-SLO from 2 to 4 times for a range of 14.6 to 33.6 months. All eyes had open-angle glaucoma with deep defects in the superior visual field (VF) near fixation as defined by 10(-2) VFs with 5 or more points less than - 15 dB; two of the eyes had deep defects in the inferior VF as well. AO-SLO images were obtained around the temporal edge of the disc. Results: In 4 of the 6 eyes, the edge of the inferior-temporal disc region of the retinal nerve fiber (RNF) defect seen on AO-SLO moved closer to fixation within 10.6 to 14.7 months. In 4 eyes, RNF bundles in the affected region appeared to lose contrast and/or disappear. Conclusions: Progressive changes in RNF bundles associated with deep defects on 10-2 VFs can be seen within about 1 year with AO-SLO imaging. These changes are well below the spatial resolution of the 10-2 VF. On the other hand, subtle thinning of regions with RNF bundles is not easy to see with current AO-SLO technology, and may be better followed with OCT. Translational Relevance: AO-SLO imaging may be useful in clinical trials designed to see very small changes in deep defects.
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