期刊
ROYAL SOCIETY OPEN SCIENCE
卷 4, 期 11, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsos.170764
关键词
quinoline; indole; tetra-n-butylammonium fluoride (TBAF); anti-microbial activity
资金
- UGC, New Delhi
A new series of indole-based pyranoquinoline derivatives P1-24 has been synthesized by a one-pot cyclocondensation reaction of 2-(4-substituted) phenyl-N-allyl-indole-3-carbaldehydes 1a-d; active methylenes 2a-c; and 4-hydroxy-1-substituted quinolin-2(1H)-one 3a-b catalysed by an organocatalyst tetra-n-butylammonium fluoride (TBAF) in aqueous ethanol. The easy experimental procedure of the reaction leads to excellent yields of pyranoquinoline derivatives. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than standard drugs as evident from the structural activity relationship study.
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