期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 3, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1056332
关键词
Aging; autophagy; Caenorhabditis elegans; homeostasis; mitochondria; mitophagy; stress; tumorigenesis
类别
资金
- European Research Council
- European Commission 7th Framework Program
- Greek General Secretariat for Research and Technology
Mitophagy is a conserved, mitochondria-specific autophagic clearance process. We recently discovered an intricate regulatory network that balances mitophagy with mitochondrial biogenesis. Proper coordination of these opposing processes is important for stress resistance and longevity. Nodal regulatory factors that contribute to mitochondrial homeostasis have also been linked to carcinogenesis, highlighting mitophagy as a potential target for therapeutic interventions against cancer.
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