期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 3, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1010948
关键词
akt; ATF3; PTEN; prostate cancer
类别
资金
- NIH/NCI [R01CA139107, R01CA1640 06]
Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genetic evidence supporting the role of ATF3 as a tumor suppressor in a subset of prostate cancers with PTEN dysfunction.
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