期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 10, 页码 2375-2383出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00278
关键词
lignin; nanocarrier; drug-delivery; laccase; miniemulsion
资金
- Bio-Based Industries Joint Undertaking under the European Union's Horizon research and innovation program BioRescue
Lignin is an abundant biopolymer that is mainly burned for energy production today. However, using it as a polyfunctional macromolecular building block would be desirable. Herein, Kraft lignin was modified through esterification of its hydroxyl groups with methacrylic anhydride. Then lignin nanocarriers with different morphologies (solid nanoparticles, core shell structures, porous nanoparticles) were produced by a combination of mini emulsion polymerization and a solvent evaporation process. A UV-active cargo is used as a drug model to investigate the release behavior of the lignin nanocarriers depending on their morphology. To prove the enzymatic response of the lignin nanocarriers, we tested the enzyme laccase as a trigger to release the encapsulated cargo. Furthermore, porous lignin nanoparticles with high surface area were produced by carbonization. The carbon material has a high potential as an adsorbent, which was studied by adsorption tests with methylene blue. These biodegradable nanocarriers based on the polyfunctional bioresource lignin may find useful application as novel drug delivery vehicle in agriculture or as carbon materials for water purification.
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