期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 4, 期 2, 页码 294-301出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00041
关键词
invasive tumour; cancer mechanobiology; 3D microenvironment; microfluidics; biomaterials; extravasation; traction forces
资金
- Cancer Research UK [C57744/A22057]
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7 under REA [625500]
- Wellcome Trust Massachusetts Institute of Technology Fellowship [WT103883]
- U.S. National Cancer Institute [U01 CA202177-01]
- NATIONAL CANCER INSTITUTE [U01CA202177] Funding Source: NIH RePORTER
- Cancer Research UK [22057] Funding Source: researchfish
In addition to a multitude of genetic and biochemical alterations, abnormal morphological, structural, and mechanical changes in cells and their extracellular environment are key features of tumor invasion and metastasis. Furthermore, it is now evident that mechanical cues alongside 1 are biochemical signals contribute to critical steps of cancer initiation, progression, and spread. Despite its importance, it is very challenging to study mechanics of different steps of metastasis in the clinic or even in animal models. While considerable progress has been made in developing advanced in vitro models for studying genetic and biological aspects of cancer, less attention has been paid to models that can capture both biological and mechanical factors realistically. This is mainly due to lack of appropriate models and measurement tools. After introducing the central role of mechanics in cancer metastasis, we provide an outlook on the emergence of novel in vitro assays and their combination with advanced measurement technologies to probe and recapitulate mechanics in conditions more relevant to the metastatic disease.
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