期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 8, 页码 1627-1640出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00086
关键词
micromotor; mushroom; chemotaxis; cancer; drug delivery
资金
- DST Nano-Mission program [SR/NM/NS-1109/2012]
- DeitY [5(9)/2012-NANO]
- DST-FIST, Government of India [SR/FST/ETII-028/2010]
- CIF, IIT Guwahati
- DBT Program Support Facility, Department of Biotechnology, IIT Guwahati
We report controlled migrations of an intelligent and biocompatible iMushbot composed of Agaricus bisporus, mushroom microcapsules coated with magnetite nanoparticles. The otherwise randomly moving microbot could meticulously direct itself toward and away from the acid- and alkali-rich regions with the help of acid, acidic catalase, and alkali stimuli, emulating the chemotaxis of microorganisms. Although the catalytic decomposition of peroxide-fuel in alkali engendered the directed alkali taxis toward higher pH region, decomposition of peroxide fuel by the acidic catalase activity led to directed acid taxis toward the lower pH region. The presence of magnetite nanoparticles not only helped in improving the activity of the motor through the heterogeneous catalytic decomposition of the peroxide fuel but also provided a remote magnetic control on the chemotaxis. The mesoporous iMushbots having negative zeta-potential could easily be loaded with the cationic anticancer drugs, which were magnetically guided toward the cancerous cells to cause apoptosis. The iMushbots exhibited higher degree of drug retaining capacity inside alkaline pH and showed facile drug release preferentially in the lower pH environments. The experiments show the potential of the iMushbots in retaining and transporting drugs in alkaline medium such as human blood and releasing them in acidic medium such as the cancerous tissues for cell apoptosis.
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