期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 10, 页码 2293-2301出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00432
关键词
MAX phase; Ti(2)AIN; cytocompatibility; in vitro test; first-principles calculations
资金
- National Natural Science Foundation of China [91226202, 91426304]
- CAS
- Ningbo Natural Science Foundation [2016A610273]
- China Scholarship Council (CSC) [201608260009]
Herein, the cytocompatibility of selected MAX phases, Ti(3)AIC(2), Ti3SiC2, and Ti(2)AIN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti(2)AIN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiC Oy layer on Ti(3)AIC(2) and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti(2)AIN had a stronger affinity to the Ca2+ ions, which indicated the good cytocomatibility of Ti(2)AIN.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据