期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 12, 页码 3128-3132出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00561
关键词
nanofiber; self-assembly; coiled-coil; vaccine; self-adjuvanting
资金
- U.S. National Institutes of Health [NIBIB 5R01EB009701, NIAID 5R01AI118182]
A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+ T-cell responses without supplemental adjuvants in mice. Epitopes studied included a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), the universal CD4+ T-cell epitope PADRE, and the model CD8+ T-cell epitope SIINFEKL, each of which could be incorporated into supramolecular multiepitope nanofibers in a modular fashion.
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