期刊
FOOD & FUNCTION
卷 7, 期 10, 页码 4432-4441出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6fo00685j
关键词
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资金
- Adaptable and Seamless Technology Transfer Program through target-driven R&D from the Japan Science and Technology Agency [AS262Z02620N]
- Research Institute for Science and Engineering, Waseda University
Piceatannol (3,3', 4', 5-trans-tetrahydroxystilbene) is a polyphenolic compound abundant in the seeds of passion fruit (Passiflora edulis). Piceatannol is an analogue of resveratrol (3, 4', 5-trans-trihydroxystilbene) and shares the structural motif and biological activities such as activation of SIRT1. Several studies have shown that piceatannol is more potent than resveratrol. In this study, we examined the effects of piceatannol on neural stem cell differentiation into astrocytes compared with those of resveratrol. At a concentration of 2.5 mu M, piceatannol promoted astrocyte differentiation, while resveratrol had no effect at this concentration. Furthermore, we found that oral administration of piceatannol increased the number of astrocytes in the brains of adult mice, while resveratrol administration showed no effects. These results suggest that piceatannol has a superior effect to resveratrol in promoting astrocyte differentiation.
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