期刊
FRONTIERS IN PSYCHIATRY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2017.00126
关键词
biomarker; developmental disorders; autism spectrum disorder; attention-deficit/hyperactivity disorder; growth factors; cytokines; cerebral cortex; cognitive impairment
类别
资金
- Consejo Nacional de Ciencia y Tecnologia (CONACyT) [PN 201501-465, INFR-280414, 736339]
- Red Tematica Celulas Troncales y Medicina Regenerativa [271609]
Growth factors (GFs) are cytokines that regulate the neural development. Recent evidence indicates that alterations in the expression level of GFs during embryogenesis are linked to the pathophysiology and clinical manifestations of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). In this concise review, we summarize the current evidence that supports the role of brain-derived neurotrophic factor, insulin-like growth factor 2, hepatocyte growth factor (HGF), glial-derived neurotrophic factor, nerve growth factor, neurotrophins 3 and 4, and epidermal growth factor in the pathogenesis of ADHD and ASD. We also highlight the potential use of these GFs as clinical markers for diagnosis and prognosis of these neurodevelopmental disorders.
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