期刊
FRONTIERS IN ENDOCRINOLOGY
卷 8, 期 -, 页码 1-20出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2017.00030
关键词
leptin; leptin receptor; activation; signaling; cross-talk; leptin resistance
资金
- IUAP [P6/36]
- ERC Advanced Grant [340941-CYRE]
Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the body weight by balancing food intake and energy expenditure. However, this adipocyte-derived hormone also directs peripheral processes, including immunity, reproduction, and bone metabolism. Leptin, therefore, can act as a metabolic switch connecting the body's nutritional status to high energy consuming processes. We provide an extensive overview of current structural insights on the leptin-ObR interface and ObR activation, coupling to signaling pathways and their negative regulation, and leptin functioning under normal and pathophysiological conditions (obesity, autoimmunity, cancer,.). We also discuss possible cross-talk with other receptor systems on the receptor (extracellular) and signaling cascade (intracellular) levels.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据