期刊
FRONTIERS IN ENDOCRINOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2017.00267
关键词
microbiota; obesity; metabolism; dysbiosis; diet; probiotics; fecal transplant; co-metabolism
资金
- postdoctoral fellowship of the Peter und Traudl Engelhorn Stiftung
- European Research Council under the European Union's Seventh Framework Programme (FP)/ERC Grant [336607 (ERC-2013-StG-336607)]
- Swiss National Science Foundation Professorship grants [PP00P3_144886, PP00P3_172906]
- Swiss National Science Foundation (SNF) [PP00P3_144886, PP00P3_172906] Funding Source: Swiss National Science Foundation (SNF)
The intestinal microbiota is a plastic ecosystem that is shaped by environmental and genetic factors, interacting with virtually all tissues of the host. Many signals result from the interplay between the microbiota with its mammalian symbiont that can lead to altered metabolism. Disruptions in the microbial composition are associated with a number of comorbidities linked to the metabolic syndrome. Promoting the niche expansion of beneficial bacteria through diet and supplements can improve metabolic disorders. Reintroducing bacteria through probiotic treatment or fecal transplant is a strategy under active investigation for multiple pathological conditions. Here, we review the recent knowledge of microbiota's contribution to host pathology, the modulation of the microbiota by dietary habits, and the potential therapeutic benefits of reshaping the gut bacterial landscape in context of metabolic disorders such as obesity.
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