期刊
INFECTION AND DRUG RESISTANCE
卷 10, 期 -, 页码 201-207出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S135420
关键词
Northeast; North; Brazil; direct sequencing; treatment failure
资金
- National Counsel of Technological and Scientific Development (CNPq) [478322/2012-7]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Brasil sem Miseria (BSM, Brazil without Misery) fellowship
Background and aims: Resistance mutation analogs to nucleos(t) ides have been described in treatment-naive patients with chronic hepatitis B (CHB), with clinical implications. The aim of this study was to investigate primary resistance mutations and genotypes circulating in patients naive to chronic hepatitis B, in the Northern and Northeastern regions of Brazil. Methods: We conducted a study of resistance mutations and genotypic characterization of hepatitis B virus (HBV) in 189 treatment-naive patients chronically infected with HBV. Results: Drug resistance-associated mutations located in the RT domain of the P gene (rtHBV) were found in 6% of the treatment-naive patients from the Northeastern Region. The mutations were rtA194T, rtL180M + rtM204V, rtS202I, rtM204I, and rtA181S. No patient in the Northern Region had the resistance mutation. In the gene S region, the frequency of vaccine escape mutations was 2.4% in the Northeastern Region and 8.6% in the Northern Region. Conclusion: This information before the start of treatment may contribute to clinical decision making, reducing treatment failure and the risk of progression to cirrhosis and hepatocellular carcinoma for CHB.
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