期刊
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
卷 5, 期 1, 页码 92-97出版社
WILEY
DOI: 10.1002/acn3.501
关键词
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资金
- Intellectual and Developmental Disabilities Research Center at the Children's Hospital of Philadelphia [IDDRC - NIH U54 HD086984]
- National Institutes of Health [NIH-R01DC008871-07]
In this repeated measures case study, we show that sensory deafferentation after limb amputation leads to changes in cortical somatotopic maps which are reversible after restoration of sensory input. Using magnetoencephalography (MEG), we observed in a child with bilateral hand transplants large-scale shifts in somatosensory lip cortical representation from anatomic hand area to anatomic face region. After recovery of tactile sensation in the digits, responses to finger stimulation were localized to orthotopic sensory cortex, but with atypical electrophysiologic features (amplitude and frequencies).
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