期刊
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
卷 4, 期 12, 页码 888-896出版社
WILEY
DOI: 10.1002/acn3.497
关键词
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资金
- NINDS [R01 NS40337, R01 NS44370]
- Congressionally Directed Medical Research Program of the (CDMRP) Department of Defense [PR093963]
- National Institutes of Health
- CDMRP [547012, PR093963] Funding Source: Federal RePORTER
Objective: Status epilepticus (SE) is a neurological emergency requiring rapid termination of seizures. New treatment choices are needed for benzodiazepine-refractory SE or established SE (ESE). Previous studies have demonstrated that the potassium-channel opener flupirtine terminates seizures in neonatal animals. However, its effectiveness in adult ESE has not been tested. We tested whether flupirtine alone or in combination with the benzodiazepine diazepam would terminate ESE in three animal models. Methods: SE was induced by administration of lithium followed by pilocarpine, by electrical stimulation of the hippocampus or by diisopropylfluorophosphate (DFP) administration. Seizures were assessed by EEG recorded from the hippocampus and cortex. Results: Flupirtine alone did not terminate ESE within 60 min of administration in any of the three models of ESE. A combination of flupirtine and diazepam terminated ESE within 60 min in all the three models. The drug combination shortened the duration of ESE in all three models. Drug responsiveness was distinct between each model. Conclusion: A combination of the potassium channel opener flupirtine and diazepam is a potential therapy for ESE.
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