期刊
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
卷 4, 期 11, 页码 835-840出版社
WILEY
DOI: 10.1002/acn3.471
关键词
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资金
- Alzheimer's Research UK [ART-SRF2010-3]
- Brain Research Trust
- Wolfson Foundation
- Alzheimer's Society [AS-PG-16-007]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre [CBRC 161]
- UCL Leonard Wolfson Experimental Neurology Centre [PR/ylr/18575]
- DANA Foundation
- Medical Research Council
- Wellcome Trust [091673/Z/10/Z]
- MRC [MR/M009106/1] Funding Source: UKRI
- Medical Research Council [1332624, MR/M009106/1, 1332163] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10033] Funding Source: researchfish
Auditory dysfunction under complex, dynamic listening conditions is a clinical hallmark of Alzheimer's disease (AD) but challenging to measure and manage. Here, we assessed understanding of sinewave speech (a paradigm of degraded speech perception) and general cognitive abilities in 17 AD patients, before and following a 10 mg dose of donepezil. Relative to healthy older individuals, patients had impaired sinewave speech comprehension that was selectively ameliorated by donepezil. Our findings demonstrate impaired perception of degraded speech in AD but retained perceptual learning capacity that can be harnessed by acetylcholinesterase inhibition, with implications for designing communication interventions and acoustic environments in dementia.
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