期刊
POLYMERIC GENE DELIVERY SYSTEMS
卷 -, 期 -, 页码 41-64出版社
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s41061-017-0131-x
关键词
Gene therapy; Electrostatic interaction; Hydrophobic interaction; Hydrogen bond; Nucleic acid; Polymer; DNA; siRNA
Gene therapy is an important therapeutic strategy in the treatment of a wide range of genetic disorders. Polymers forming stable complexes with nucleic acids (NAs) are non-viral gene carriers. The self-assembly of polymers and nucleic acids is typically a complex process that involves many types of interaction at different scales. Electrostatic interaction, hydrophobic interaction, and hydrogen bonds are three important and prevalent interactions in the polymer/nucleic acid system. Electrostatic interactions and hydrogen bonds are themain driving forces for the condensation of nucleic acids, while hydrophobic interactions play a significant role in the cellular uptake and endosomal escape of polymer-nucleic acid complexes. To design high-efficiency polymer candidates for the DNA and siRNA delivery, it is necessary to have a detailed understanding of the interactions between them in solution. In this chapter, we survey the roles of the three important interactions between polymers and nucleic acids during the formation of polyplexes and summarize recent understandings of the linear polyelectrolyte-NA interactions and dendrimer-NAinteractions. Wealso reviewrecent progress optimizing the gene delivery system by tuning these interactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据