期刊
CELL SYSTEMS
卷 4, 期 5, 页码 559-+出版社
CELL PRESS
DOI: 10.1016/j.cels.2017.04.011
关键词
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资金
- National Science Foundation [DMR-1206146, DMR-1610737, MRSEC-1420382]
- Simons Foundation through a Targeted Grant in the Mathematical Modeling of Living Systems
- Boehringer Ingelheim Fonds
- Arthur Klorfein Scholarship and Fellowship Fund
- Mountain Memorial Fund Scholarship
- Howard A. Schneiderman Endowed Scholarship
- Burroughs-Wellcome Fund of the Physiology Course at the Marine Biological Laboratory
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1610737] Funding Source: National Science Foundation
How the size of micrometer-scale cellular structures such as the mitotic spindle, cytoskeletal filaments, the nucleus, the nucleolus, and other non-membrane bound organelles is controlled despite a constant turnover of their constituent parts is a central problem in biology. Experiments have implicated the limiting-pool mechanism: structures grow by stochastic addition of molecular subunits from a finite pool until the rates of subunit addition and removal are balanced, producing a structure of well-defined size. Here, we consider these dynamics when multiple filamentous structures are assembled stochastically from a shared pool of subunits. Using analytical calculations and computer simulations, we show that robust size control can be achieved only when a single filament is assembled. When multiple filaments compete for monomers, filament lengths exhibit large fluctuations. These results extend to three-dimensional structures and reveal the physical limitations of the limiting-pool mechanism of size control when multiple organelles are assembled from a shared pool of subunits.
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