期刊
CELL SYSTEMS
卷 4, 期 4, 页码 445-+出版社
CELL PRESS
DOI: 10.1016/j.cels.2017.02.013
关键词
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资金
- Advanced Investigator European Research Council grant MEXTIM
- Biotechnology and Biological Sciences Research Council [BB/J004588/1]
- John Innes Foundation Rotation PhD Studentship
- BBSRC [BBS/E/J/000CA447, BBS/E/J/000PR9773] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000PR9773, BBS/E/J/000CA447] Funding Source: researchfish
Genes targeted by Polycomb repressive complex 2 (PRC2) are regulated in cis by chromatin modifications and also in trans by diffusible regulators such as transcription factors. Here, we introduce a mathematical model in which transcription directly antagonizes Polycomb silencing, thereby linking these cis- and trans-regulatory inputs to gene expression. The model is parameterized by recent experimental data showing that PRC2-mediated repressive chromatin modifications accumulate extremely slowly. The model generates self-perpetuating, bistable active and repressed chromatin states that persist through DNA replication, thereby ensuring high-fidelity transmission of the current chromatin state. However, sufficiently strong, persistent activation or repression of transcription promotes switching between active and repressed chromatin states. We observe that when chromatin modification dynamics are slow, transient pulses of transcriptional activation or repression are effectively filtered, such that epigenetic memory is retained. Noise filtering thus depends on slow chromatin dynamics and may represent an important function of PRC2-based regulation.
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