期刊
SCIENCE BULLETIN
卷 62, 期 22, 页码 1504-1509出版社
SCIENCE PRESS
DOI: 10.1016/j.scib.2017.10.016
关键词
Lewis acid catalysed; Mukaiyama-aldol reaction; Ketones; Difluoroenoxysilanes; beta-Hydroxy alpha,alpha-difluoro ketones
资金
- National Basic Research Program of China [2015CB856600]
- National Natural Science Foundation of China [21472049]
We report a general and highly efficient Mukaiyama-aldol reaction of ketones and difluoroenoxysilanes. While the reaction of aryl ketones worked efficiently in the presence of Bi(OTf)(3), that of aliphatic ketones required the use of Sc(OTf)(3). In addition, Sc(OTf)(3) was capable of achieving excellent 1,2-selectivity in the corresponding reaction of alpha,beta-unsaturated ketones. This method provides a facile access to differently substituted beta-hydroxy alpha,alpha-difluoro ketones, versatile synthons for difluomethylated tertiary alcohols. (C) 2017 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据