期刊
NATURE REVIEWS CANCER
卷 16, 期 12, 页码 775-788出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc.2016.105
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资金
- Instituto de Salud Carlos III [PI13/00763, CP10/00624]
- European Regional Development Fund (ERDF)
- Ligue contre le cancer (Comites de Charente, de Charente-maritime, des Deux-Sevres, du Morbihan et de la Vienne)
- National Institutes of Health [GM55632]
- Canadian Institutes of Health Research, Canadian Cancer Society and Canada Research Chairs Program
- Canadian Institutes of Health Research [130530, 123228]
- Canadian Cancer Society [701459]
- Canada Research Chair Program
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. Although many studies support the notion that connexins are tumour suppressors, recent evidence suggests that, in some tumour types, they may facilitate specific stages of tumour progression through both junctional and non-junctional signalling pathways. This Timeline article highlights the milestones connecting gap junctions to cancer, and underscores important unanswered questions, controversies and therapeutic opportunities in the field.
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