期刊
BIONANOSCIENCE
卷 6, 期 4, 页码 352-354出版社
SPRINGER
DOI: 10.1007/s12668-016-0232-y
关键词
Nuclear magnetic resonance; Fluvastatin; Micelles; Molecular complex
Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.
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