期刊
ORGANIC CHEMISTRY FRONTIERS
卷 4, 期 11, 页码 2092-2096出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qo00590c
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资金
- Natural Sciences and Engineering Research Council (NSERC)
- University of Ottawa
The alkylative semipinacol rearrangement of a variety of TMS protected alpha-styrenyl substituted cyclic alcohols with unactivated bromoalkanes that merge photoredox and Au(I)/Au(III) catalysis has been achieved. This redox neutral rearrangement is marked by a dimeric Au(I) photocatalyst that plays two roles; photoredox activation of bromoalkanes and Au(III)-mediated semipinacol rearrangement coupled with C(sp(3))-C(sp(3)) reductive elimination; a reaction mode rarely accessed. This operationally simple methodology contains readily available starting materials that undergo reaction with [Au-2(dppm)(2)]Cl-2 upon irradiation with UVA LEDs, furnishing diversified ketone products. Primary, secondary, and tertiary bromoalkanes and a range of TMS protected a-styrenyl substituted alcohols were investigated in this transformation.
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