期刊
ORGANIC CHEMISTRY FRONTIERS
卷 4, 期 12, 页码 2358-2363出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qo00621g
关键词
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资金
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02-06]
- Fundamental Research Funds for the Central Universities [201562031, 201762011]
Tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives bearing four stereogenic centers were achieved via an asymmetric organocatalytic cascade process with excellent stereoselectivity in one single operation and H2O as the only side product. The alpha,beta-unsaturated carboxylic acid plays two important roles in the cascade process: the Michael acceptor and acidic co-catalyst for enamine catalysis.
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