Copper-catalyzed oxidative dehydrogenative coupling of carboxylic acids with H-phosphonates: an efficient and practical approach to acyl phosphate esters

A copper-catalyzed oxidative dehydrogenative coupling of carboxylic acids with H-phosphonates is developed. This transformation exhibits a wide substrate scope and good functional group tolerance, providing a straightforward and highly efficient access to acyl phosphate esters. A possible mechanism for the reaction is proposed.