期刊
ORGANIC CHEMISTRY FRONTIERS
卷 4, 期 8, 页码 1513-1516出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qo00249a
关键词
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资金
- National Natural Science Foundation of China [21272190]
- NFFTBS [J1310024]
An expeditious strategy for the synthesis of pyrazolo[5,1-a]isoquinolines has been developed. The tricyclic scaffolds are formed through a four-step cascade sequence, including copper(II)-catalyzed regioselective bicyclization, nucleophilic addition of H2O, aerobic oxidation, and aromatization through eliminating a molecule of TsH. The synthetic utility of this method is demonstrated through the synthesis of a potential CDC25B inhibitor.
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