期刊
OPTICA
卷 4, 期 8, 页码 924-931出版社
OPTICAL SOC AMER
DOI: 10.1364/OPTICA.4.000924
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资金
- Carl Zeiss Meditec AG [CD 10260501]
- EXALOS AG [CD 10260501]
- Bundesministerium fur Wissenschaft, Forschung und Wirtschaft (BMWFW) [CD 10260501]
- Austrian Science Fund (FWF) [P29093-N36]
- Austrian Science Fund (FWF) [P29093] Funding Source: Austrian Science Fund (FWF)
High-resolution imaging of the human retina has always been a challenge due to imperfect optical properties of the human cornea and lens, which limit the achievable resolution. We present a noniterative digital aberration correction (DAC) to achieve aberration-free cellular-level resolution in optical coherence tomography (OCT) images of the human retina in vivo. The system used is a line-field spectral-domain OCT system with a high tomogram rate, reaching 2.5 kHz. Such a high speed enables us to successfully apply digital aberration correction for not only imaging of human cone photoreceptors but also to obtain an aberration- and defocus-corrected 3D volume. Additionally, we apply DAC on functional OCT angiography data to improve lateral resolution and compensate for defocus. The speed necessities for the use of DAC in patient imaging are quantified by measuring the axial motion of 36 subjects. The first demonstration of DAC on OCT angiography as well as the motion analysis is important for future work dealing with DAC. (C) 2017 Optical Society of America
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