期刊
IBRO REPORTS
卷 1, 期 -, 页码 19-31出版社
ELSEVIER
DOI: 10.1016/j.ibror.2016.08.001
关键词
TrkB receptor; Treadmill running; Hyperphosphorylated Tau; Early neurodegeneration; Aging; Hippocampus
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/15495-2, 2013/08028-1, 2015/189612]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [471999/2013-0, 401670/2013-9]
- FAPESP [2011/15281-0, 2011/00478-2, 2011/15283-2]
- CNPq [377060/2015-1, 374198/2015-2]
Physical exercise can attenuate the effects of aging on the central nervous system by increasing the expression of neurotrophins such as brain-derived neurotrophic factor (BDNF), which promotes dendritic branching and enhances synaptic machinery, through interaction with its receptor TrkB. TrkB receptors are synthesized in the cell body and are transported to the axonal terminals and anchored to plasma membrane, through SLP1, CRMP2 and Rab27B, associated with KIF1B. Retrograde trafficking is made by EDH-4 together with dynactin and dynein molecular motors. In the present study it was found that early neurodegeneration is accompanied by decrease in BDNF signaling, in the absence of hyperphosphorylated tau aggregation, in hippocampus of 11 months old Lewis rats exposed to rotenone. It was also demonstrated that moderate physical activity (treadmill running, during 6 weeks, concomitant to rotenone exposure) prevents the impairment of BDNF system in aged rats, which may contribute to delay neurodegeneration. In conclusion, decrease in BDNF and TrkB vesicles occurs before large aggregate-like p-Tau are formed and physical activity applied during early neurodegeneration may be of relevance to prevent BDNF system decay. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization.
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