期刊
ONCOIMMUNOLOGY
卷 7, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2017.1373236
关键词
Immune checkpoint; Immunotherapy; TNFR2; Treg; Immunomodulation
资金
- Fondation pour la recherche medicale
- Fondation Ramsay Generale de Sante
Three recent publications identified the TNF/TNR2 pathway as a new target to reduce graft-versus-host-disease through regulatory T cells activation or to potentially switch on a strong anti-leukemic effect through regulatory T cells blockade in allogeneic hematopoietic stem cell transplantation. This identified the TNF/TNR2 pathway as a swith and as a new target for immune checkpoint therapy to modulate the immune regulation in this clinical setting.
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