期刊
ONCOIMMUNOLOGY
卷 6, 期 2, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2016.1273302
关键词
Adoptive T-cell therapy; breast cancer; immunosuppression; lung cancer; mesothelioma; PD-1 blockade; tumor microenvironment
资金
- National Institutes of Health [P30 CA008748]
- U.S. Department of Defense [BC132124]
- Memorial Sloan Kettering's Office of Technology Development
- Mr. William H. Goodwin and Alice Goodwin
- Commonwealth Foundation for Cancer Research
- Experimental Therapeutics Center
PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells provides cell-intrinsic checkpoint blockade and augments antitumor efficacy. A combinatorial immunotherapeutic strategy of combining CAR T cells with checkpoint blockade is a promising treatment approach for solid tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据