4.8 Review

China's flourishing synthetic organofluorine chemistry: innovations in the new millennium

期刊

NATIONAL SCIENCE REVIEW
卷 4, 期 3, 页码 303-325

出版社

OXFORD UNIV PRESS
DOI: 10.1093/nsr/nwx058

关键词

fluorine; organic chemistry; synthetic methods; fluorination; trifluoromethylation; trifluoromethylthiolation; difluoromethylation; difluoroalkylation; fluoromethylation; fluoroolefination

资金

  1. National Natural Science Foundation of China [21632009, 21472221, 21421002, 21372246]
  2. National Basic Research Program of China [2015CB931900]
  3. Key Programs of the Chinese Academy of Sciences [KGZD-EW-T08]
  4. Key Research Program of Frontier Sciences of CAS [QYZDJ-SSW-SLH049]
  5. Shanghai Academic Research Leader Program [15XD1504400]
  6. Shanghai Rising-Star Program [16QA1404600]
  7. Youth Innovation Promotion Association CAS [2014231]

向作者/读者索取更多资源

The new millennium has witnessed the rapid development of synthetic organofluorine chemistry all over the world, and chemists in China have made significant contributions in this field. This review aims to provide a brief introduction to China's primary innovations from 2000 to early 2017, covering fluorination, fluoroalkylation, fluoromethylthiolation, fluoroolefination and polyfluoroarylation, as well as synthesis with fluorinated building blocks. Recent advances in the chemistry of difluorocarbene and the chemistry of carbon-fluorine bond activation are also discussed. As a conclusion, the review ends with some personal perspectives on the future development of China's synthetic organofluorine chemistry.

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