期刊
VACCINES
卷 4, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/vaccines4040046
关键词
T cell; metabolism; immunotherapy; cancer; tumor microenvironment; metabolic checkpoints
资金
- Sidney Kimmel Foundation for Cancer Research [SKF-015-039]
- Skin Cancer Specialized Programs Of Research Excellence (SPORE) [P50CA121973]
- Innovative Research Grant from Stand Up To Cancer
- American Association for Cancer Research [SU2C-AACR-IRG-04-16]
When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates metabolic checkpoints upon infiltrating T cells, impacting their ability to survive, proliferate and function effectively. In this review, we summarize the basics of tumor cell and T cell metabolism and discuss recent advances elucidating the individual metabolic checkpoints exerted on T cells that drive their dysfunction in the TME.
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