期刊
MOLECULAR AND CLINICAL ONCOLOGY
卷 5, 期 6, 页码 671-674出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mco.2016.1050
关键词
human papillomavirus; cancer of unknown primary; hypopharyngeal cancer; head and neck cancer; oropharyngeal cancer
类别
资金
- Swedish Cancer Foundation
- Stockholm Cancer Society
- Cancer and Allergy Foundation
- Stockholm City Council
- Karolinska Institutet, Sweden
Human papillomavirus (HPV), in addition to smoking and alcohol, is a cause of oropharyngeal squamous cell carcinoma (OPSCC), particularly of the tonsils and base of the tongue (TSCC and BOTSCC, respectively). Moreover, HPV-positive TSCC and BOTSCC are associated with a better outcome compared with their HPV-negative counterparts (80 vs. 40% 3-year disease-free survival rate, respectively) and their incidence has increased in several countries. Recently, accumulating evidence of HPV in a considerable proportion of cancers of unknown primary (CUP) in the head and neck region and in a small proportion of hypopharyngeal SCCs has been reported. Furthermore, HPV-positive tumours, particularly cases with HPV DNA positivity in combination with overexpression of p16, also tend to have a better clinical outcome compared with that of the corresponding HPV-negative tumours. This finding is particularly prominent in HPV-positive CUPs of the head and neck region, where the primary tumour likely originates from the oropharynx. Thus, the determination of HPV status and p16 expression may be of value for the diagnosis and treatment of CUP of the head and neck region and may also be of value for hypopharyngeal cancers in the future. However, for hypopharyngeal cancer as well as other non-OPSCCs, additional studies per subsite on the effect of HPV status on survival are required.
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