期刊
BIOACTIVE MATERIALS
卷 1, 期 2, 页码 93-108出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2016.11.001
关键词
Bioactive; Biomaterials; Scaffold; Porosity; Biodegradable; Tissue regeneration
资金
- National Institute of Health [5R03NS058595]
- Connecticut Regenerative Medicine Research Fund [15-RMBUCHC-08]
- National Science Foundation [IIP-1311907, IIP-1355327, EFRI-1332329]
- Department of Defense [OR120140]
- Emerging Frontiers & Multidisciplinary Activities
- Directorate For Engineering [1332329] Funding Source: National Science Foundation
A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity. Traditional scaffold fabrication techniques often failed to create intricate structures with greater resolution, not reproducible and involved multiple steps. The 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug delivery. This review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores, bioactivity and degradation rate to enable tissue regeneration. Review highlights few examples of bioactive scaffold mediated nerve, muscle, tendon/ligament and bone regeneration. Regardless of the efforts required for optimization, a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined. (C) 2016 The Authors. Production and hosting by Elsevier B. V. on behalf of KeAi Communications Co., Ltd.
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