期刊
EMERGING INFECTIOUS DISEASES
卷 22, 期 12, 页码 2104-2112出版社
CENTERS DISEASE CONTROL
DOI: 10.3201/eid2212.160450
关键词
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资金
- Research Project of H7N9 Influenza of Guangdong [1046]
- Scientific, Technological Research of Prevention and Control of H7N9 Subtype Avian Influenza Virus [20140024]
- China Scholarship Council [201508440009]
- MRC [MR/L009528/1] Funding Source: UKRI
- Medical Research Council [MR/L009528/1] Funding Source: researchfish
Since March 2013, three waves of human infection with avian influenza A(H7N9) virus have been detected in China. To investigate virus transmission within and across epidemic waves, we used surveillance data and whole-genome analysis of viruses sampled in Guangdong during 2013-2015. We observed a geographic shift of human A(H7N9) infections from the second to the third waves. Live poultry market interventions were undertaken in epicenter cities; however, spatial phylogenetic analysis indicated that the third-wave outbreaks in central Guangdong most likely resulted from local virus persistence rather than introduction from elsewhere. Although the number of clinical cases in humans declined by 35% from the second to the third waves, the genetic diversity of third-wave viruses in Guangdong increased. Our results highlight the epidemic risk to a region reporting comparatively few A(H7N9) cases. Moreover, our results suggest that live-poultry market interventions cannot completely halt A(H7N9) virus persistence and dissemination.
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