期刊
EUROPEAN RADIOLOGY
卷 26, 期 5, 页码 1320-1329出版社
SPRINGER
DOI: 10.1007/s00330-015-3943-5
关键词
Pancreas; Neuroendocrine neoplasm; Overall survival; Recurrence free survival; CT
资金
- Ministry of Education, Science and Technology, South Korea [2012R1A1A1012731]
Objectives To evaluate the prognostic value of CT to predict recurrence-free and overall survival in patients with pancreatic neuroendocrine neoplasms (PanNENs). Methods Between January 2004 and December 2012, 161 consecutive patients who underwent preoperative triphasic CT and surgical resection with curative intent for PanNENs were identified. The tumour consistency, margin, presence of calcification, pancreatic duct dilatation, bile duct dilatation, vascular invasion, and hepatic metastases were evaluated. The tumour size, arterial enhancement ratio, and portal enhancement ratio were measured. The Cox proportional hazard model was used to determine the association between CT features and recurrence-free survival and overall survival. Results By multivariate analysis, tumour size (> 3 cm) (hazard ratio, 3.314; p = 0.006), portal enhancement ratio (a parts per thousand currency sign1.1) (hazard ratio, 2.718; p = 0.006), and hepatic metastases (hazard ratio, 4.374; p = 0.003) were independent significant variables for worse recurrence-free survival. Portal enhancement ratio (a parts per thousand currency sign1.1) (hazard ratio, 5.951; p = 0.001) and hepatic metastases (hazard ratio, 4.122; p = 0.021) were independent significant variables for worse overall survival. Conclusions Portal enhancement ratio (a parts per thousand currency sign1.1) and hepatic metastases assessed on CT were common independent prognostic factors for worse recurrence-free survival and overall survival in patients with PanNENs.
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