期刊
EUROPEAN RADIOLOGY
卷 25, 期 7, 页码 2033-2040出版社
SPRINGER
DOI: 10.1007/s00330-014-3573-3
关键词
Magnetic resonance imaging; Diffusion; Ovary; Neoplasms; Metastasis
资金
- CRUK BIDD [C1353/A12762]
- CRUK
- EPSRC Cancer Imaging Centre in association
- MRC
- Department of Health [C1060/A10334]
- NHS
- NIHR Biomedical Research Centre
- National Institute for Health Research, through the Cancer Research Network (NCRN)
- Cancer Research UK [16464, 16465, 12762] Funding Source: researchfish
- Medical Research Council [G0701533] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10162] Funding Source: researchfish
- MRC [G0701533] Funding Source: UKRI
To assess goodness-of-fit and repeatability of mono-exponential, stretched exponential and bi-exponential models of diffusion-weighted MRI (DW-MRI) data in primary and metastatic ovarian cancer. Thirty-nine primary and metastatic lesions from thirty-one patients with stage III or IV ovarian cancer were examined before and after chemotherapy using DW-MRI with ten diffusion-weightings. The data were fitted with (a) a mono-exponential model to give the apparent diffusion coefficient (ADC), (b) a stretched exponential model to give the distributed diffusion coefficient (DDC) and stretching parameter (alpha), and (c) a bi-exponential model to give the diffusion coefficient (D), perfusion fraction (f) and pseudodiffusion coefficient (D*). Coefficients of variation, established from repeated baseline measurements, were: ADC 3.1 %, DDC 4.3 %, alpha 7.0 %, D 13.2 %, f 44.0 %, D* 165.1 %. The bi-exponential model was unsuitable in these data owing to poor repeatability. After excluding the bi-exponential model, analysis using Akaike Information Criteria showed that the stretched exponential model provided the better fit to the majority of pixels in 64 % of lesions. The stretched exponential model provides the optimal fit to DW-MRI data from ovarian, omental and peritoneal lesions and lymph nodes in pre-treatment and post-treatment measurements with good repeatability. aEuro cent DW-MRI data in ovarian cancer show deviation from mono-exponential behaviour aEuro cent Parameters derived from the stretched exponential model showed good repeatability (CV 7 %) aEuro cent The bi-exponential model was unsuitable because of poor parameter repeatability aEuro cent The stretched exponential model showed comparable repeatability to the mono-exponential model aEuro cent The extra parameter (alpha) provides scope for investigation of heterogeneity or response.
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