期刊
EUROPEAN RADIOLOGY
卷 26, 期 4, 页码 1009-1017出版社
SPRINGER
DOI: 10.1007/s00330-015-3920-z
关键词
Magnetic resonance imaging; Cardiovascular physiological processes; Cardiac imaging technique; Isometric exercise; Exercise test
资金
- British Heart Foundation
- British Heart Foundation [PG/11/98/29201, PG/10/76/28545, FS/08/012/24454] Funding Source: researchfish
- Great Ormond Street Hospital Childrens Charity [V1404] Funding Source: researchfish
- National Institute for Health Research [ACF-2011-14-016] Funding Source: researchfish
Introduction Isometric exercise may unmask cardiovascular disease not evident at rest, and cardiovascular magnetic resonance (CMR) imaging is proven for comprehensive resting assessment. This study devised a simple isometric exercise CMR methodology and assessed the hemodynamic response evoked by isometric exercise. Methods A biceps isometric exercise technique was devised for CMR, and 75 healthy volunteers were assessed at rest, after 3-minute biceps exercise, and 5-minute of recovery using: 1) blood pressure (BP) and 2) CMR measured aortic flow and left ventricular function. Total peripheral resistance (SVR) and arterial compliance (TAC), cardiac output (CO), left ventricular volumes and function (ejection fraction, stroke volume, power output), blood pressure (BP), heart rate (HR), and rate pressure product were assessed at all time points. Results Image quality was preserved during stress. During exercise there were increases in CO (+14.9 %), HR (+17.0 %), SVR (+9.8 %), systolic BP (+22.4 %), diastolic BP (+25.4 %) and mean BP (+23.2 %). In addition, there were decreases in TAC (-22.0 %) and left ventricular ejection fraction (-6.3 %). Age and body mass index modified the evoked response, even when resting measures were similar. Conclusions Isometric exercise technique evokes a significant cardiovascular response in CMR, unmasking physiological differences that are not apparent at rest.
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