期刊
JOURNAL OF ORAL MICROBIOLOGY
卷 9, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/20002297.2017.1344509
关键词
Fluoride; Streptococcus mutans; antimicrobial resistance; dental caries
类别
资金
- National Natural Science Foundation of China [81371135]
For decades, fluoride has been used extensively as an anti-caries agent. It not only protects dental hard tissue, but also inhibits bacterial growth and metabolism. The antimicrobial action of fluoride is shown in three main aspects: the acidogenicity, acidurance, and adherence to the tooth surface. To counteract the toxic effect of fluoride, oral bacteria are able to develop resistance to fluoride through either phenotypic adaptation or genotypic changes. Strains that acquire fluoride resistance through the latter route show stable resistance and can usually resist much higher fluoride levels than the corresponding wild-type strain. This review summarizes the characteristics of fluoride-resistant strains and explores the mechanisms of fluoride resistance, in particular the recent discovery of the fluoride exporters. Since the fluoride resistance of the cariogenic bacterium Streptococcus mutans has been studied most extensively, this review mainly discusses the findings related to this species.
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