期刊
JOURNAL OF ORAL MICROBIOLOGY
卷 9, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/20002297.2017.1340085
关键词
P. gingivalis; keystone pathogen; commensal microbiota; complement; animal model; periodontitis
类别
资金
- European Commission [FP7-HEALTH-306029]
- U.S. National Institutes of Health [AI003040, AI068730]
- European Community's Seventh Framework Programme (DIREKT) [602699]
- US National Institutes of Health [DE015254, DE021685, DE024153, DE024716, DE026152]
Porphyromonas gingivalis is a Gram-negative anaerobic rod that has been proposed as an orchestrator of complement-dependent dysbiotic inflammation. This notion was suggested from its capacities to manipulate the complement-Toll-like receptor crosstalk in ways that promote dysbiosis and periodontal disease in animal models. Specifically, while at low colonization levels, P. gingivalis interferes with innate immunity and leads to changes in the counts and composition of the oral commensal microbiota. The resulting dysbiotic microbial community causes disruption of host-microbial homeostasis, leading to inflammatory bone loss. These findings suggested that P. gingivalis can be considered as a keystone pathogen. The concept of keystone pathogens is one where their effects have community-wide significance and are disproportionate of their abundance. The present review summarizes the relevant literature and discusses whether the results from the animal models can be extrapolated to man.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据