Synergism between Pfcrt and Pfmdr 1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal

Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly stable in Ghana several years after official disuse of chloroquine. Certain mutations in Pfmdr 1 may potentiate Pfcrt T76, offering a possible explanation for this observation. To understand the phenomenon, the coexistence of mutations in Pfmdr 1 with Pfcrt T76 in Ghanaian Plasmodium falciparum