期刊
JOURNAL OF CELL COMMUNICATION AND SIGNALING
卷 12, 期 1, 页码 21-29出版社
SPRINGER
DOI: 10.1007/s12079-017-0423-5
关键词
TRIM proteins; Ubiquitin; E3 ligase; Leukaemia; Lymphoma; Multiple myeloma
类别
资金
- Bloodwise [15043] Funding Source: Medline
Post-translational modification of proteins with ubiquitin plays a central role in regulating numerous cellular processes. E3 ligases determine the specificity of ubiquitination by mediating the transfer of ubiquitin to substrate proteins. The family of tripartite motif (TRIM) proteins make up one of the largest subfamilies of E3 ligases. Accumulating evidence suggests that dysregulation of TRIM proteins is associated with a variety of diseases. In this review we focus on the involvement of TRIM proteins in blood cancers.
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