期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
卷 5, 期 2, 页码 369-375出版社
ELSEVIER
DOI: 10.1016/j.jaip.2016.11.020
关键词
IgE; Food allergy; Eosinophilic esophagitis; Oral immunotherapy; Prevalence
资金
- American Academy of Pediatrics
- Stuart Starr Endowed Chair of Pediatrics
- Children's Hospital of Philadelphia Eosinophilic Esophagitis Fund
- Consortium of Eosinophilic Gastrointestinal Disease Researchers, Rare Disease Clinical Research Network, an initiative of National Center for Advancing Translational Sciences (NCATS) Office of Rare Disease Research [U54 AI117804]
- NCATS and collaborating institute centers
BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that is triggered by food allergens and characterized by progressive esophageal dysfunction. Recently, EoE has been identified in patients who underwent oral immunotherapy (OIT) for IgE-mediated food allergy, suggesting an association. OBJECTIVE: We sought to ascertain whether significant associations exist between IgE-mediated food allergies and EoE. METHODS: Using the analysis of electronic medical record data and manual chart review, we examined our subspecialty care network of 35,528 children and adolescents to identify and characterize patients with IgE-mediated and EoE food allergy. The most common food allergens were defined, and the prevalence of EoE in patients with IgE-mediated food allergy was determined. Logistic regression was used to measure the extent to which IgE-mediated food allergy to specific foods is associated with EoE. RESULTS: The most common causes of EoE were milk, soy, egg, grains, and meats, an allergen pattern that is distinct from that of IgE-mediated food allergy. The prevalence of EoE in patients with IgE-mediated food allergy was higher than that reported in the general population (4.7% vs 0.04%). The distribution of IgE-mediated food allergens in patients with EoE was similar to that of the general population, and IgE-mediated allergy to egg (2.27; 1.91-2.64), milk (4.19; 3.52-4.97), or shellfish (1.55; 1.24-1.92) was significantly associated with an EoE diagnosis. CONCLUSIONS: Our findings support a clinical association between these conditions that has implications for the management of children with food allergy, and particular relevance to patients undergoing OIT. (C) 2016 American Academy of Allergy, Asthma & Immunology
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