期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms17101700
关键词
antipsychotic; aripiprazole; asenapine; atypical; clozapine; olanzapine; quetiapine; risperidone; second-generation; suicide; ziprasidone
资金
- Bruce J. Anderson Foundation
- McLean Private Donors Psychopharmacology Research Fund
Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general. These preliminary findings encourage further testing of antipsychotics for effects on suicidal behavior, making use of explicit, pre-planned assessments of suicidal behavior.
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